|
KMID : 0613820170270040482
|
|
Journal of Life Science
2017 Volume.27 No. 4 p.482 ~ p.499
|
|
|
Allergy Immunity Regulation and Synergism of Bifidobacteria
|
|
Cho Kwang-Keun
Choi In-Soon
|
|
|
Abstract
|
|
|
|
Allergic diseases have increased over the past several decade worldwide including developing countries. Allergic inflammatory responses are caused by Th (T helper)2 immune responses, triggered by allergen ingestion by antigen presenting cells such as dendritic cells (DCs). Intestinal microorganisms control the metabolism and physiological functions of the host, contribute to early immune system maturation during the early life, and homeostasis and epithelial integrity during life. Bifidobacteria have strain-specific immunostimulatory properties in the Th1/Th2 balance, inhibit TSLP (thymic stromal lymphopoietin) and IgE expression, and promote Flg (Filaggrin) and FoxP3 (Treg) expression to alleviate allergies. In addition, unmethylated CpG motif ODN (oligodeoxynucleotides) is recognized by TLR (toll-like receptors)9 of B cells and plasmacytoid dendritic cells (pDCs) to induce innate and adaptive immune responses, while the butyrate produced by Clostridium butyricum activates the GPR (G-protein coupled receptors)109a signaling pathway to induce the expression of anti-inflammatory gene of pDCs, and directly stimulates the proliferation of thymically derived regulatory T (tTreg) cells through the activation of GPR43 or inhibits the activity of HADC (histone deacetylase) to differentiate naive CD4? T cells into pTreg cells through the histone H3 acetylation of Foxp3 gene intronic enhancer.
|
|
|
KEYWORD
|
|
|
Allergy, Bifidobacteria, Butyrate, Clostridium butyricum, CpG ODN
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|